Infectious Diseases: Dengue Virus NS2B-NS3 Protease Inhibitors
Franziska von Hammerstein, Andrea Gellert, Benedikt Millies, Stefan Hammerschmidt, Steven Holloway, Hongmei Wu, Thomas Weidner & AG Bodem (Universität Würzburg) & AK Diederich (Universität Marburg) & Ute Hellmich (Institut für Biochemie, Johannes Gutenberg-Universität Mainz)
Dengue, a mosquito-borne viral infection of humans, has become a continuing global threat since 2.5 billion people living in tropical and subtropical regions of the word are at risk of infection. The dengue virus infection can result in classic dengue fever, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Our projects include syntheses, characterization and testing of inhibitors. Possible binding modes are analyzed by molecular docking studies. Additionally microscale thermophoresis is used in order to quantify ligand-protein-interactions.